Mechanobiology of Embryonic Limb Development

Reproductive Biomechanics Mechanobiology of Embryonic Limb Development

Considerable evidence exists to support the hypothesis that mechanical forces have an essential influence on embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle contractions for limb development. However, the influence of these forces is seldom referred to in biological descriptions of bone development, and perhaps this is due to the fac...

Mechanobiology of embryonic skeletal development: Insights from animal models.

A range of clinical conditions in which fetal movement is reduced or prevented can have a severe effect on skeletal development. Animal models have been instrumental to our understanding of the interplay between mechanical forces and skeletal development, particularly the mouse and the chick model systems. In the chick, the most commonly used means of altering the mechanical environment is by p...

Mechanobiology of Embryonic Skeletal Development: Insights from Animal Models For Publication in issue on: "CURRENT ANALYSES OF EMBRYONIC DEVELOPMENT"

Mechanobiology in the development, maintenance, and degeneration of articular cartilage.

During skeletal development, the establishment of a layer of cartilage at the ends of long bones is intimately linked to the process of endochondral ossification. Previous in vivo studies and computer models suggest that mechanobiological factors can play a key role in modulating cartilage growth and ossification. Specifically, intermittent hydrostatic pressure is thought to maintain cartilage,...

Effect of dorsal and ventral limb ectoderm on the development of the limb of the embryonic chick.

Limb ectoderm plus a small amount of subjacent mesoderm obtained from the dorsal or the ventral surface of each of the four limbs of the chick embryo were grafted to the dorsal surface of the right wing in either reversed or normal orientation. The host wings developed in abnormal humerus in all cases except when the graft was obtained from the dorsal surface of the right wing and was in normal...